Key result
Obesity in children and adolescents was associated with significantly higher HOMA-IR, TNF-α, and visfatin levels, and lower adiponectin levels compared to controls.
Case-Control (n=90)
Obesity in children and adolescents is associated with altered circulating levels of adipokines, specifically higher visfatin and TNF-α and lower adiponectin, which may contribute to metabolic risk.
Supports adipokine monitoring for metabolic risk in obese youth; hypothesis-generating pending prospective validation.
BACKGROUND: Childhood obesity is a global epidemic and is associated with a higher risk of chronic diseases such as hypertension, diabetes mellitus and other metabolic disorders. Several adipokines including resistin, visfatin, leptin and adiponectin are synthesized and secreted by adipocytes, which play an important role in obesity. PATIENTS & METHODS: A total of 90 subjects (60 controls and 30 obese) between the ages of 5 and 18 years were selected. Serum visfatin, TNF-α, resistin, insulin and adiponectin were measured using ELISA and insulin resistance was calculated by the Homeostasis Model of Assessment-Insulin Resistance. RESULTS: Mean ± standard deviation Homeostasis Model of Assessment-Insulin Resistance, serum TNF-α and visfatin levels were significantly higher in obese subjects (3.99 ± 0.94, 12.99 ± 3.42, 10.89 ± 2.72, respectively) compared with the control group (1.60 ± 0.34, 7.22 ± 2.22 and 4.97 ± 1.57, respectively). Mean ± standard deviation serum adiponectin levels were significantly lower in obese children (5.95 ± 1.02) compared with controls (9.07 ± 1.25). Binary logistic regression shows that adiponectin and visfatin are associated with obesity. CONCLUSION: Circulating levels of adipokines vary in obesity and adiponectin and visfatin are associated with obesity.
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Jaleel et al. (2013) conducted a case-control in Obesity (n=90). Obesity vs. Controls was evaluated on Serum visfatin, TNF-α, resistin, insulin, adiponectin, and HOMA-IR. Obesity in children and adolescents was associated with significantly higher HOMA-IR, TNF-α, and visfatin levels, and lower adiponectin levels compared to controls.
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