Updated Clinical Classification of Pulmonary Hypertension
Key result
The 2013 updated PH classification maintains the prior scheme but removes PPHN from Group 1.
Why the study?
The clinical classification of pulmonary hypertension required updates to reflect new understanding and to create a comprehensive classification for both adults and children.
Comparison
Updated classification vs previous clinical classification
Design
Consensus from 5th World Symposium on Pulmonary Hypertension
Authors
Discussion
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Member takes
Implication
Consensus review demonstrates updated categorization criteria for pulmonary hypertension in affected cohorts, highlighting refined diagnostic boundaries for tailored therapeutic management.
Key Points
- To revise and update the clinical classification of pulmonary hypertension, aligning diagnostic groups with evolving pathophysiological insights and therapeutic advances.
- Convened international multidisciplinary expert panels to review hemodynamic definitions and clinical trial evidence.
- Evaluated clinical, genetic, and pathological criteria across five established diagnostic categories of pulmonary hypertension.
- Retained the five comprehensive diagnostic groups while refining subcategories for pulmonary arterial hypertension, left heart disease, and lung disorders.
- Lowered the diagnostic hemodynamic threshold to a resting mean pulmonary arterial pressure greater than 20 mmHg with pulmonary vascular resistance of at least 3 Wood units.
- Clarified classification rules for vasoreactivity testing, drug and toxin exposure, and congenital heart anomalies to optimize patient management.
PICO
P
Population
Pulmonary hypertension
Cite This Study
Simonneau et al. (2013) conducted a review in Pulmonary hypertension. The 2013 updated clinical classification of pulmonary hypertension maintained the previous general scheme while withdrawing persistent pulmonary hypertension of the newborn from Group 1.