Key result
CYP11B2 and ACE polymorphisms show no association with LV mass, function, or dilatation in hypertension.
Why the study?
The association of aldosterone synthase -344C/T and ACE I/D polymorphisms with left ventricular mass, function, and dilatation in hypertensive patients with normal coronary arteries was unclear.
Are aldosterone synthase -344C/T and ACE I/D polymorphisms associated with left ventricular mass, function, and dilatation in hypertensive patients with normal coronary arteries?
Cross-Sectional (n=88)
Are aldosterone synthase -344C/T and ACE I/D polymorphisms associated with left ventricular mass, function, and dilatation in hypertensive patients with normal coronary arteries?
The studied RAAS polymorphisms (ACE I/D and CYP11B2 -344C/T) do not appear to predict left ventricular structural or functional changes in Turkish hypertensive patients.
BACKGROUND: The renin-angiotensin-aldosterone system (RAAS) plays an important role in blood pressure regulation, left ventricular and vascular structure. Some hypertensive patients develop left ventricular dilatation and heart failure symptoms while others are relatively less affected. The purpose of our study was to determine whether two major polymorphisms of RAAS are associated with echocardiographic left ventricular mass, function and dilatation in hypertensive patients with normal coronary arteries. METHODS: A Turkish population of 88 patients with hypertension and normal coronary arteries were studied by echocardiography for left ventricular dimension, mass and function. Genotyping was performed for aldosterone synthase (CYP11B2) -344C/T polymorphism in 85, angiotensin-converting enzyme (ACE) I/D polymorphism in 88 patients. Left ventricular dimensions, mass and function indices, after adjustment for clinical covariates, were analysed by multiple regression according to genotypes. RESULTS: None of the two genotypes studied predicted left ventricular dilatation, mass or function in hypertensive patients with normal coronary arteries. CONCLUSION: Neither ACE I/D nor CYP11B2 -344C/T polymorphisms were useful to predict left ventricular mass, function or dilatation in our hypertensive patients with normal coronary arteries.
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Olcay et al. (2006) conducted a cross-sectional in Hypertension with normal coronary arteries (n=88). Aldosterone synthase (CYP11B2) -344C/T and ACE I/D polymorphisms vs. Alternative genotypes was evaluated on Left ventricular dilatation, mass or function. Aldosterone synthase -344C/T and ACE I/D polymorphisms were not associated with left ventricular mass, function, or dilatation in hypertensive patients with normal coronary arteries.
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