Optical coherence tomography angiography findings in noninfectious posterior uveitis: a controlled study

Purpose:To analyze the microvascular parameters using optical coherence tomography angiography (OCTA) in noninfectious posterior uveitis (PU) patients. Material and Methods:In this cross-sectional study, OCTA images of patients with noninfectious PU were evaluated.The vessel densities (VD) in the superficial and deep capillary plexuses (SCP & DCP), foveal avascular zone (FAZ) area were measured and compared to healthy controls.Results: The study cohort comprised 64 patients with age and gender-matched groups.The VD in the SCP was 43.9±3.9% in the whole image; 18.4±4.8% in the fovea, 43.9±4.6% in the parafoveal area, and 43.4±9.7% in the perifoveal zone, in the eyes with PU.These were respectively 48.8±2.9%,22.9±6.9%,50.9±3.0%,and 49.2±3.1% in the control group (p=0.0001,0.043, 0.0001, 0.01, respectively).The changes in the DCP in eyes with PU were not significant.In the PU group, the FAZ was significantly enlarged compared to controls (0.37±0.1 microns vs. 0.24±0.2microns, p=0.046).Conclusion: OCTA depicted significant changes, including decreased VD in the SCP and enlarged FAZ in noninfectious PU.