Key result
Adipokine profiles correlate with metabolic syndrome components in obese pubertal children.
Why the study?
The relationship between serum adiponectin, resistin, and RBP4 levels and components of metabolic syndrome in pubertal obese children was not well characterized.
Are serum adiponectin, resistin, and RBP4 levels associated with metabolic syndrome components in obese pubertal children?
Cross-Sectional (n=148)
Are serum adiponectin, resistin, and RBP4 levels associated with metabolic syndrome components in obese pubertal children?
Adiponectin, RBP4, and resistin levels correlate with metabolic syndrome components and may serve as predictive biomarkers in obese pubertal children.
Answers are grounded in this paper and cite their sources.
These correlations in obese youth are hypothesis-generating; prospective studies needed before any clinical biomarker role.
AIM: To investigate the relationship between serum adiponectin, resistin and RBP4 levels and the components of metabolic syndrome. PATIENTS & METHODS: Serum adiponectin, resistin and RBP4 levels were detected and analyzed in 148 8-18-year-old Turkish obese pubertal children with/without metabolic syndrome. RESULTS: Adiponectin and resistin concentrations were significantly inversely correlated with BMI standard deviation score, homeostatic model assessment insulin resistance, waist circumference, triglyceride levels and diastolic and systolic blood pressure, and were directly correlated with high-density lipoprotein cholesterol. RBP4 concentrations were directly correlated with homeostatic model assessment insulin resistance, waist circumference, triglyceride levels and diastolic and systolic blood pressure, and inversely correlated with high-density lipoprotein cholesterol. CONCLUSION: Adiponectin, RBP4 and, in particular, resistin levels may be used as suitable predictive biomarkers of metabolic syndrome.
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Boyraz et al. (2013) conducted a cross-sectional in Obesity and metabolic syndrome (n=148). Serum adiponectin, resistin and RBP4 levels was evaluated on Correlation with metabolic syndrome components (BMI standard deviation score, HOMA-IR, waist circumference, triglycerides, blood pressure, HDL cholesterol). Serum adiponectin and resistin levels were inversely correlated, and RBP4 directly correlated, with metabolic syndrome components in 148 obese pubertal children.
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