Key result
Combat zone exposure is linked to uncontrolled hypertension rising to ~89% among civilian patients.
Why the study?
The features of the course of hypertension and type 2 diabetes in combination during a long-term stay in combat zones remain unstudied.
Does a long stay in a combat zone worsen the course of disease in civilian patients with hypertension and type 2 diabetes?
Observational (n=65)
No
Does a long stay in a combat zone worsen the course of disease in civilian patients with hypertension and type 2 diabetes?
Absolute Event Rate: 89% vs 6%
p-value: p=<0.05
Long-term exposure to a combat zone significantly worsens blood pressure and glycemic control in civilian patients with comorbid hypertension and type 2 diabetes, leading to increased cardiovascular and cerebrovascular events.
Wartime stress effects on hypertension-T2DM comorbidity remain incompletely defined; prospective studies needed before clinical implications.
Background. In modern conditions, an acute problem in medicine is the issue of a negative impact of war on the course of chronic noncommunicable diseases. The most common of them are hypertension and type 2 diabetes mellitus, which in most cases occur as a comorbidity. To date, a certain amount of work has been carried out to study the influence of war and chronic wartime stress on the development and progression of hypertension. However, the features of the course of hypertension and type 2 diabetes in case of their combination during a long-term stay of patients in combat zones remain unstudied. The purpose: to study changes in the nature of the disease course in patients with hypertension and type 2 diabetes — representatives of the civilian population after a long stay in the combat zone of the Kharkiv region of Ukraine. Materials and methods. Sixty-five patients (civilians) with hypertension and type 2 diabetes (30 men, 35 women) aged from 47 to 64 years were examined. All of them were examined before the start of the war and 4–5 months after staying in the combat zone. Results. In hypertensive patients with type 2 diabetes after their stay in a combat zone, hypertension became more severe (in 89 % of cases, it was uncontrolled, the frequency of hypertensive crisis and resistant hypertension increased significantly). In addition, a significant increase in the frequency of decompensation of carbohydrate metabolism was detected. The examined patients showed a progression of lipid metabolism disorders and the development of new cases of cardiovascular and cerebrovascular diseases. Conclusions. There was a pronounced negative impact of long-term stay of patients with hypertension and type 2 diabetes in a combat zone on the course of both hypertension and diabetes, which was associated with a significant increase in the incidence of cardiovascular and cerebrovascular diseases.
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Koval et al. (2024) conducted an observational in Hypertension and type 2 diabetes mellitus (n=65). Long stay in a combat zone vs. Baseline (before the war) was evaluated on Uncontrolled hypertension (p=<0.05). Long-term stay in a combat zone significantly worsened disease control in civilians with hypertension and type 2 diabetes, increasing the prevalence of uncontrolled hypertension from 6% to 89%.
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