Key result
Longer HIV duration is linked to ~14% higher daytime hypertension risk per year.
Why the study?
There is a scarcity of data on ambulatory blood pressure in HIV-infected individuals with high office blood pressure.
Does HIV duration predict ambulatory blood pressure and hypertension in HIV-infected individuals with high office blood pressure?
Cohort (n=77)
Does HIV duration predict ambulatory blood pressure and hypertension in HIV-infected individuals with high office blood pressure?
Odds Ratio: 1.14 (95% CI 1.03–1.26)
Longer duration of HIV infection is an independent predictor of elevated ambulatory blood pressure and hypertension in patients with high office blood pressure.
HIV duration may inform ABP risk in untreated patients; leaves open independent predictive value and need for prospective validation.
OBJECTIVE: There is a scarcity of data on ambulatory blood pressure (ABP) in HIV-infected individuals. The aim of the study was to identify possible predictors of ABP in HIV-infected individuals. METHODS: From a cohort of 542 HIV-infected patients, ABP monitoring was undertaken in 77 patients with high office blood pressure (BP) readings and without antihypertensive treatment. RESULTS: 24-h and daytime ABPs were associated with HIV duration (r=0.24-0.33, p=0.004-0.033), but not with duration of combined antiretroviral therapy. In multivariate linear regression analyses with the different ABPs as dependent variables, HIV duration (unstandardized beta=0.41-0.89, p=0.008-0.045) and log-transformed urinary albumin excretion (p=0.003-0.043) were predictors of all 24-h and daytime ABPs. Multiple logistic regression analysis revealed HIV duration (OR=1.14/year (95% CI 1.03-1.26)) as predictor of hypertension defined according to daytime ABP. Nocturnal hypertension was observed in 81%, white coat hypertension was present in 26%. CONCLUSIONS: HIV duration was an independent predictor of ABP and hypertension in a selected group of HIV-infected individuals. Nocturnal hypertension was prevalent, and white coat hypertension was present in one fourth of the patients.
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Manner et al. (2010) conducted a cohort in HIV infection with high office blood pressure (n=77). HIV duration was evaluated on Hypertension defined according to daytime ABP (OR 1.14, 95% CI 1.03-1.26). Longer HIV duration was an independent predictor of hypertension defined by daytime ambulatory blood pressure (OR 1.14 per year; 95% CI 1.03-1.26) in patients with high office blood pressure.
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