Key result
CT-derived end-systolic eccentricity index independently predicts pulmonary vascular resistance in CTEPH.
Why the study?
The usefulness of biventricular function parameters measured by enhanced MDCT pulmonary angiography in patients with CTEPH has not been clarified.
Does end-systolic eccentricity index obtained by enhanced MDCT predict pulmonary vascular resistance in patients with chronic thromboembolic pulmonary hypertension?
Cohort (n=80)
No
Does end-systolic eccentricity index obtained by enhanced MDCT predict pulmonary vascular resistance in patients with chronic thromboembolic pulmonary hypertension?
p-value: p=<0.009
End-systolic eccentricity index obtained by enhanced MDCT is a simple and independent predictor of pulmonary vascular resistance and disease severity in patients with CTEPH.
esEI from MDCT may support noninvasive PVR estimation in CTEPH; leaves open its utility for risk stratification or treatment guidance.
The usefulness of the parameters of biventricular function simultaneously measured using enhanced multi-detector computed tomography (MDCT) pulmonary angiography in patients with chronic thromboembolic pulmonary hypertension (CTEPH) has not been clarified. This study aimed to verify the correlation between left and right ventricular (RV) parameters and pulmonary vascular resistance (PVR). Patients who underwent enhanced MDCT before diagnostic right heart catheterization at Nagoya University Hospital between October 2014 and April 2021 were enrolled. The correlation of biventricular function and volume parameters with PVR was assessed. Eighty patients were retrospectively analyzed. Patients’ mean age was 65 ± 13 years, mean PVR was 9.1 (range, 6.1−11.3) Wood units, and mean end-systolic eccentricity index (esEI) was 1.76 ± 0.50. RV end-systolic volume (ESV) (p = 0.007), RV cardiac output (CO) (p < 0.001), RV ejection fraction (p < 0.001), LV end-diastolic volume (EDV) (p < 0.001), left ventricular (LV) ESV (p = 0.006), LVCO (p < 0.001), end-diastolic EI (p < 0.001), and esEI (p < 0.001) were significantly correlated with PVR. The LVEDV (p = 0.001) and esEI (p < 0.009) were independent predictors of PVR. Systolic pulmonary arterial pressure (PAP) (p < 0.001), diastolic PAP (p < 0.001), mean PAP (p < 0.001), right atrial pressure (p < 0.023), and PVR (p < 0.001) were significantly higher in the high esEI group than in the low esEI group. The esEI was a simple predictor of CTEPH severity.
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Tsutsumi et al. (2022) conducted a cohort in Chronic thromboembolic pulmonary hypertension (CTEPH) (n=80). End-systolic eccentricity index (esEI) vs. Low esEI group was evaluated on Pulmonary vascular resistance (PVR) (p=<0.009). End-systolic eccentricity index obtained by enhanced computed tomography was an independent predictor of pulmonary vascular resistance in patients with CTEPH (P<0.009).
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