Key result
Jejunoileal bypass for morbid obesity yielded 35-37% weight loss at 2 years but was associated with high morbidity, including ~50% rehospitalization and 8% bypass-related mortality.
Why the study?
What are the long-term weight loss and complication rates of jejunoileal bypass surgery in patients with morbid obesity?
Cohort (n=230)
What are the long-term weight loss and complication rates of jejunoileal bypass surgery in patients with morbid obesity?
While jejunoileal bypass surgery results in substantial weight loss, it is associated with severe long-term metabolic complications, high rehospitalization rates, and significant mortality.
Documents frequent metabolic and arthritic complications after jejunoileal bypass; leaves open relevance to current bariatric techniques.
Since 1962, jejunoileal bypass has been performed on 59 male and 171 female subjects, aged 18 to 55 years; these patients were followed clinically. Postoperative weight loss at two years averaged 37% in men and 35% in women. Hypokalemia (23%), hypocalcemia (22%), hypoalbuminemia (9%), metabolic acidosis (14%), elevated liver enzyme values (41%), and hyperbilirubinemia (6%), were the most commonly encountered blood chemical alterations. Complications were arthritis syndrome (men, 8%; women, 19%), urinary calculi (men, 24%; women, 10%), cholelithiasis (men, 10%; women, 9%), liver impairment (men, 2%; women, 6%), and major emotional upset (men, 8%; women, 9%). Forty-nine percent of the men and 51% of the women required rehospitalization for management of complications, surgery for hernia, anorectal disorders, nutritional support, and metabolic study. There were 19 bypass-related deaths (8%), including 10 due to liver failure. (JAMA236:2298-2301, 1976)
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L. T. DeWind (1976) conducted a cohort in morbid obesity (n=230). Jejunoileal bypass was evaluated on Postoperative weight loss, complications, and mortality. Jejunoileal bypass for morbid obesity yielded 35-37% weight loss at 2 years but was associated with high morbidity, including ~50% rehospitalization and 8% bypass-related mortality.
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