Key result
Amantadine hydrochloride overdose caused a fatal outcome in a psychiatric patient being treated for neuroleptic-induced extrapyramidal side effects.
This case report highlights the risk of fatal overdose with amantadine hydrochloride when used for neuroleptic-induced extrapyramidal side effects.
May warrant overdose vigilance with amantadine for EPS; single case leaves open need for systematic safety data.
The authors describe the first case report in the psychiatric literature of death from an overdose of amantadine hydrochloride used to treat neuroleptic induced extrapyramidal side effects. The pharmacology, adverse reactions and risks of using amantadine are briefly reviewed.
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Cook et al. (1986) studied this question. Amantadine hydrochloride overdose caused a fatal outcome in a psychiatric patient being treated for neuroleptic-induced extrapyramidal side effects.
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