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November 1, 1995Journal of Molecular and Cellular CardiologyOpen Access

Stimulus-dependent Subcellular Localization of Activated Protein Kinase C; a Study with Acidic Fibroblast Growth Factor and Transforming Growth Factor- 1 in Cardiac Myocytes

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Key result

aFGF and TGF-beta 1 induce distinct subcellular localization of activated PKC isozymes in cardiomyocytes.

Why the study?

PKC isozymes vary in sensitivity and subcellular localization upon stimulation by different growth factors in cardiac myocytes, which may underlie divergent cardiac functions.

Population

Neonatal rat ventricular myocytes in culture

Comparison

Stimulation with acidic fibroblast growth factor vs transforming growth factor-beta 1

Design

Preclinical experimental study with immunocytochemical analysis

Authors

MDMarie‐Hélène DisatnikStanford UniversitySJShekira Nashone JonesDMDaria Mochly‐RosenHeart Failure & Transplant

Discussion

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Implication

Supports PKC isoform specificity in neonatal myocytes; leaves open translation to adult human cardiac disease.

Structured PICO

P
Population
Neonatal rat ventricular myocytes in culture
I
Intervention
Stimulation with acidic fibroblast growth factor (aFGF) and transforming growth factor-beta 1 (TGF-beta 1)
O
Outcome
Subcellular localization and sensitivity of PKC isozymessurrogate

Different growth factors (aFGF and TGF-beta 1) induce distinct subcellular localization of PKC isozymes in cardiac myocytes, providing a molecular basis for their divergent cardiac functions.

Cite This Study

Disatnik et al. (1995) studied this question. Acidic fibroblast growth factor (aFGF) and transforming growth factor-beta 1 (TGF-beta 1) was evaluated on Subcellular localization of activated PKC isozymes. Stimulation of neonatal rat ventricular myocytes with aFGF and TGF-beta 1 resulted in distinct subcellular localization of activated PKC isozymes.

synapsesocial.com/papers/6ab63cf5c21d028cecfb8a85https://doi.org/10.1006/jmcc.1995.0235
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Localization of Protein Kinase C Isozymes in Cardiac Myocytes1994 · 335 citations
  2. 2Distinct Regulation of Cardiac Fibroblast Proliferation and Transdifferentiation by Classical and Novel Protein Kinase C Isoforms: Possible Implications for New Antifibrotic Therapies2020 · 15 citations
  3. 3Expression of a constitutively activated mutant of the beta-isozyme of protein kinase C in cardiac myocytes stimulates the promoter of the beta-myosin heavy chain isogene1991 · 164 citations
  4. 4Studies on the calcium- and phospholipid- dependent protein kinase activity from heart2008
  5. 5Stimulus-specific Differences in Protein Kinase Cδ Localization and Activation Mechanisms in Cardiomyocytes2004 · 109 citations