Key result
Chinese elite female soccer athletes had significantly different ACTN3 R577X genotype frequencies compared to controls (XX 0%, XR 53.3%, RR 46.7% vs XX 16%, XR 44%, RR 40%; p=0.007).
Why the study?
Are ACE I/D and ACTN3 R577X polymorphisms associated with athletic performance and VO2max in Chinese elite female soccer athletes?
Case-Control (n=260)
Are ACE I/D and ACTN3 R577X polymorphisms associated with athletic performance and VO2max in Chinese elite female soccer athletes?
p-value: p=0.007
The combination of ACE II/ID and ACTN3 RR/XR genotypes may be a synergetic determinant of athletic performance and VO2max in Chinese female soccer athletes.
ACTN3 R577X genotype frequencies were associated with elite soccer status in Chinese women; hypothesis-generating and should not yet change practice.
OBJECTS: We investigated the association of ACE I/D and ACTN3 R577X polymorphisms with the performance of Chinese elite female soccer athletes for the first time. MATERIAL AND METHODS: The genotype distributions of ACE I/D and ACTN3 R577X in the athlete group and the control group of Chinese females were evaluated via PCR and compared. VO2max value was tested as per standard protocol. RESULTS: Regarding the distribution of ACE polymorphisms, the genotype frequency was indifferent between the athletes (II 40 %, ID 46.7 %, DD 13.3 %) and the controls (II 42 %, ID 48 %, DD 10 %). No difference in the I/D allele frequency was observed between the athlete group and the control group. Regarding the distribution of ACTN3 polymorphisms, the genotype frequency was significantly different between the athletes (XX 0 %, XR 53.3 %, RR 46.7 %) and the controls (XX 16 %, XR 44 %, RR 40 %). The allele frequency was observed no different between the athlete and the control group. The ACE ID and ACTN3 RR genotype combination was associated with higher VO2max values among defenders than among other players. According to VO2max values,The ACE and ACTN3 genotype combinations (II/ID/DD + RR/XR) significantly differed between the athletes and the controls (p < 0.05). CONCLUSION: These results suggested that the Chinese elite female soccer athletes were more likely to harbor the I allele and the R allele and that the combination of ACE II/ID and ACTN3 RR/XR was a synergetic determinant of the athletic performance of females in soccer.
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Qi Wei (2021) conducted a case-control in Athletic performance in female soccer (n=260). ACE I/D and ACTN3 R577X polymorphisms vs. Healthy non-athlete controls was evaluated on ACTN3 R577X genotype frequency (p=0.007). Chinese elite female soccer athletes had significantly different ACTN3 R577X genotype frequencies compared to controls (XX 0%, XR 53.3%, RR 46.7% vs XX 16%, XR 44%, RR 40%; p=0.007).
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