Key result
Sodium depletion selectively increases renal cortical GC-B receptor mRNA levels ~2-fold.
Why the study?
The natriuresis and diuresis response to atrial natriuretic peptide varies with sodium status, potentially due to changes in renal natriuretic peptide receptors under transcriptional control.
Does sodium status affect natriuretic peptide receptor mRNA levels in the sheep kidney?
Comparison
Sodium-loaded and sodium-depleted sheep versus control sheep
Design
Preclinical study measuring mRNA levels of natriuretic peptide receptors
Authors
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Hypothesis-generating for transcriptional control of renal NP receptors; leaves open clinical translation to sodium handling.
Does sodium status affect natriuretic peptide receptor mRNA levels in the sheep kidney?
Sodium depletion increases GC-B receptor mRNA levels in the sheep renal cortex, suggesting an intrarenal function for the GC-B receptor and its ligand.
Fraenkel et al. (1994) studied Sodium status (n=16). Sodium depletion and sodium loading vs. Control was evaluated on mRNA levels for GC-A, GC-B and clearance (C) receptors in renal cortex and medulla. Sodium depletion increased GC-B receptor mRNA levels approximately two-fold in the sheep renal cortex, with no significant difference in GC-A and C receptor mRNA levels.
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