What is the clinical evidence from this study?

Study design: Other. Population: Salt-resistant hypertension / kidney function regulation. Intervention: GC-A gene disruption vs. Wild-type mice. Primary outcome: Natriuresis/diuresis in response to physiological saline containing 4% BSA.

April 11, 2000Proceedings of the National Academy of SciencesOpen Access

A genetic model defines the importance of the atrial natriuretic peptide receptor (guanylyl cyclase-A) in the regulation of kidney function

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Key result

Infusion of physiological saline containing 4% BSA resulted in marked natriuresis and diuresis in wild-type mice but no response in GC-A null mice.

Population

Wild-type and guanylyl cyclase-A (GC-A) null mice

Comparison

Volume expansion with physiological saline… vs Comparison between wild-type and GC-A null mice

Design

Preclinical

Authors

SDSusan K. DuboisThe University of Texas at Austin IKIchiro KishimotoKansai Medical University TLTerence O. LillisWest Virginia University

Discussion

Member takes

Implication

GC-A mediates volume-expansion natriuresis in mice; hypothesis-generating for human sodium handling and volume disorders.

Structured PICO

Population

Wild-type and GC-A null mice evaluated for kidney response to various sodium and volume challenges.

Exposure

Volume expansion with physiological saline containing 4% BSA (i.v.), physiological saline (gavage), 0.9% saline (intraperitoneal), or 0.9% NaCl lacking protein (i.v.); standard (0.7% NaCl) or high-salt (8% NaCl) diet

Comparator

Comparison between wild-type and GC-A null mice

Outcome

Kidney response (natriuresis/diuresis, sodium/water excretion)surrogate

The ANP receptor GC-A is critical for regulating sodium and water excretion during volume expansion where isooncotic pressure remains constant, but dispensable for dietary sodium changes.

Cite This Study

Dubois et al. (2000) studied Salt-resistant hypertension / kidney function regulation. GC-A gene disruption vs. Wild-type mice was evaluated on Natriuresis/diuresis in response to physiological saline containing 4% BSA. Infusion of physiological saline containing 4% BSA resulted in marked natriuresis and diuresis in wild-type mice but no response in GC-A null mice.

synapsesocial.com/papers/6a219bbb153b2036cbf1e500 https://doi.org/10.1073/pnas.97.8.4369

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April 11, 2000Proceedings of the National Academy of SciencesOpen Access

A genetic model defines the importance of the atrial natriuretic peptide receptor (guanylyl cyclase-A) in the regulation of kidney function

View Full Paper

Ask AI

Bookmark

Key result

Infusion of physiological saline containing 4% BSA resulted in marked natriuresis and diuresis in wild-type mice but no response in GC-A null mice.

Population

Wild-type and guanylyl cyclase-A (GC-A) null mice

Comparison

Volume expansion with physiological saline… vs Comparison between wild-type and GC-A null mice

Design

Preclinical

Authors

SDSusan K. DuboisThe University of Texas at Austin IKIchiro KishimotoKansai Medical University TLTerence O. LillisWest Virginia University

Discussion

Member takes

Implication

GC-A mediates volume-expansion natriuresis in mice; hypothesis-generating for human sodium handling and volume disorders.

Structured PICO

Population

Wild-type and GC-A null mice evaluated for kidney response to various sodium and volume challenges.

Exposure

Comparator

Comparison between wild-type and GC-A null mice

Outcome

Kidney response (natriuresis/diuresis, sodium/water excretion)surrogate

The ANP receptor GC-A is critical for regulating sodium and water excretion during volume expansion where isooncotic pressure remains constant, but dispensable for dietary sodium changes.

Cite This Study

synapsesocial.com/papers/6a219bbb153b2036cbf1e500 https://doi.org/10.1073/pnas.97.8.4369

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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