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September 1, 1997Journal of Biological ChemistryOpen Access

The Guanylyl Cyclase-deficient Mouse Defines Differential Pathways of Natriuretic Peptide Signaling

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Population

Wild-type mice and GC-A null mice

Comparison

Infusion of Atrial natriuretic peptide, B-type… vs Comparison of responses between wild-type and…

Design

Preclinical

Authors

MLMandi J. LopezLouisiana State UniversityDGDavid L. GarbersThe University of Texas at AustinMKMichaela KühnHeart Failure & Transplant

Discussion

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Implication

Supports GC-A specificity for ANP/BNP vasorelaxation in mice; leaves open CNP receptor identity and clinical translation.

Structured PICO

P
Population
Wild-type mice and GC-A null mice (genetically altered mice with disruption of the guanylyl cyclase-A natriuretic peptide receptor gene)
I
Intervention
Infusion of Atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), or C-type natriuretic peptide (CNP)
C
Comparator
Comparison of responses between wild-type and GC-A null mice
O
Outcome
Aortic ring relaxation in vitro and blood pressure changes in conscious mice in vivosurrogate

ANP and BNP regulate blood pressure and vascular tone specifically through the GC-A receptor, whereas CNP acts through a distinct receptor pathway.

Cite This Study

Lopez et al. (1997) studied this question.

synapsesocial.com/papers/6a8350c86cf9bd377e606ce5https://doi.org/10.1074/jbc.272.37.23064

Topics

Hypertension management
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Also Consider

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  1. 1Natriuretic Peptide Signaling via Guanylyl Cyclase (GC)-A: An Endogenous Protective Mechanism of the Heart2009 · 48 citations
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  3. 3A genetic model defines the importance of the atrial natriuretic peptide receptor (guanylyl cyclase-A) in the regulation of kidney function2000 · 39 citations
  4. 4Genetic Models Reveal That Brain Natriuretic Peptide Can Signal through Different Tissue-Specific Receptor-Mediated Pathways12000 · 38 citations
  5. 5Genetic Models Reveal That Brain Natriuretic Peptide Can Signal through Different Tissue-Specific Receptor-Mediated Pathways2000 · 15 citations