Key result
Serotonin toxicity is a potentially lethal condition caused by excess serotonin, most commonly resulting from the combination of monoamine oxidase inhibitors with selective serotonin reuptake inhibitors or selective norepinephrine reuptake inhibitors.
Prevention of serotonin toxicity requires careful prescribing, monitoring, and avoidance of multidrug regimens.
Demands avoidance of MAOI-SSRI/SNRI combinations; reinforces known risks but leaves practice change to clinician judgment.
OBJECTIVE: This review of serotonin syndrome or serotonin toxicity covers the years 2014 to 2019, including information on pathophysiology, etiology, and diagnosis, 3 criteria for diagnosing serotonin syndrome, and criteria for neuroleptic malignant syndrome. IMPORTANCE: The review highlights the potential lethal combinations of commonly prescribed medications used to treat both veteran and nonveteran patients and includes the latest information on offending medications. CONCLUSIONS: Prevention of serotonin toxicity includes informed clinicians, patient education, careful prescribing and monitoring, and avoidance of multidrug regimens.
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Cynthia Talton (2020) conducted a review in Serotonin Syndrome / Serotonin Toxicity. Serotonin-elevating medications was evaluated. Serotonin toxicity is a potentially lethal condition caused by excess serotonin, most commonly resulting from the combination of monoamine oxidase inhibitors with selective serotonin reuptake inhibitors or selective norepinephrine reuptake inhibitors.
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