Key result
Triamterene plus furosemide normalizes potassium and blood pressure in pediatric low-renin hypertension.
Why the study?
Low-renin hypertension with abnormal cortisol metabolism in very young children is rare and not well characterized.
Population
A 19-month-old boy with failure to thrive and low-renin hypertension
Comparison
Triamterene with and without furosemide after lack of response to spironolactone and dexamethasone
Design
Case report
Authors
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Hypothesis-generating for diuretic therapy in pediatric low-renin hypertension; prospective trials needed before clinical adoption.
Case Report (n=1)
Triamterene combined with furosemide successfully managed low-renin, low-aldosterone hypertension and hypokalaemia in a pediatric patient with abnormal cortisol metabolism.
Fiselier et al. (2008) conducted a case report in Low-renin, low-aldosterone hypertension and abnormal cortisol metabolism (n=1). Triamterene and furosemide was evaluated on Blood pressure and serum potassium normalization. Treatment with triamterene normalized serum potassium, and the addition of furosemide lowered blood pressure, leading to catch-up growth in a child with low-renin hypertension.
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