March 1, 1980PEDIATRICS
Familial, Dexamethasone-Suppressible, Normokalemic Hyperaldosteronism
Why the study?
Does dexamethasone therapy normalize blood pressure and hormone levels in patients with familial normokalemic hyperaldosteronism?
Population
3 family members with hypertension, low plasma renin activity, nonsuppressible plasma aldosterone after…
Design
Case_series
Authors
Discussion
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Implication
May support dexamethasone trial in suspected familial normokalemic hyperaldosteronism; leaves open confirmation in prospective studies.
Structured PICO
Does dexamethasone therapy normalize blood pressure and hormone levels in patients with familial normokalemic hyperaldosteronism?
P
Population
3 family members (an 8-year-old boy, his 6-year-old brother, and 31-year-old father) with hypertension, low plasma renin activity, nonsuppressible plasma aldosterone after saline infusion, and normal serum potassium.
I
Intervention
Dexamethasone therapy (also mentions trial of spironolactone and prednisone)
O
Outcome
Blood pressure normalization and changes in plasma/urinary aldosterone and renin levelssurrogate
Dexamethasone effectively normalizes blood pressure and aldosterone levels in familial normokalemic hyperaldosteronism, highlighting the importance of screening renin levels in hypertensive children and their parents.
Cite This Study
Grim et al. (1980) studied this question.