Why the study?
What is the aldosterone response to angiotensin II and ACTH in patients with dexamethasone-suppressible hyperaldosteronism?
Population
A family with nine siblings, including 3 with dexamethasone-suppressible hyperaldosteronism, 2 hypertensive…
Comparison
Angiotensin II infusion, dexamethasone… vs Baseline conditions and normotensive siblings
Design
Case_series
Follow-up
4 weeks
Authors
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Indicates possible zona glomerulosa impairment in this rare disorder; leaves open fasciculata origin of aldosterone, requiring confirmation in larger cohorts.
What is the aldosterone response to angiotensin II and ACTH in patients with dexamethasone-suppressible hyperaldosteronism?
The study demonstrates functional impairment of the zona glomerulosa in dexamethasone-suppressible hyperaldosteronism, supporting the hypothesis that aldosterone may be derived from the zona fasciculata in this disorder.
Fallo et al. (1985) studied this question.
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