Key result
Obstructive jaundice blunts myocardial contractile response to beta-adrenoreceptor stimulation despite intact baseline performance.
Why the study?
Patients with obstructive jaundice are susceptible to postoperative shock, but the underlying mechanism involving myocardial contractile response is unclear.
Does obstructive jaundice alter the myocardial contractile response to beta-adrenoreceptor stimulation in dogs?
Population
Dogs with chronic bile-duct ligation, choledochocaval anastomosis, and sham-operated controls
Comparison
Isoprenaline response in ventricular preparations from CBDL and CDCA dogs versus sham-operated dogs
Design
Preclinical study using isolated ventricular muscle preparations
Authors
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Depressed isoprenaline response in jaundiced canine myocardium; hypothesis-generating for postoperative shock mechanisms and requires clinical validation.
Does obstructive jaundice alter the myocardial contractile response to beta-adrenoreceptor stimulation in dogs?
Obstructive jaundice in dogs blunts the myocardial contractile response to beta-adrenergic stimulation, providing a potential mechanistic explanation for the susceptibility of jaundiced patients to postoperative shock.
Binah et al. (1985) studied Obstructive jaundice. Obstructive jaundice and/or cholaemia (CBDL and CDCA models) vs. Sham-operated dogs (SO) was evaluated on Contractile response to isoprenaline of isolated ventricular preparations. Obstructive jaundice and/or cholaemia in dogs was associated with a blunted myocardial contractile response to beta-adrenoreceptor stimulation despite intact basic mechanical performance.
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