Endothelial dysfunction in patients with exaggerated blood pressure response during treadmill test
Key result
Exercise-induced hypertension is linked to ~64% lower endothelium-dependent vasodilation vs controls.
- P<0.05
- n=50
Why the study?
The diagnostic and prognostic importance of exaggerated blood pressure response to exercise is controversial, and information on endothelial function in exercise-induced hypertension is limited.
Comparison
Patients with exercise-induced hypertension vs control subjects
Design
Case-control study using high-resolution ultrasound
Authors
Discussion
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Implication
Exercise-induced hypertension signals possible endothelial impairment meriting risk scrutiny; leaves open prognostic value and therapeutic implications.
Study Design
Type
Case-Control (n=50)
Structured PICO
P
Population
50 subjects, including 25 patients with exercise-induced hypertension and 25 controls, evaluated for endothelial function.
O
Outcome
Endothelium-dependent vasodilation of the brachial artery measured by high-resolution ultrasoundsurrogate
Main Result
Absolute Event Rate: 2.81% vs 7.77%
p-value: p=<0.05
Patients with an exaggerated blood pressure response to exercise exhibit impaired endothelium-dependent vasodilation, suggesting endothelial dysfunction plays a role in exercise-induced hypertension.
Cite This Study
Chang et al. (2004) conducted a case-control in Exercise-induced hypertension (n=50). Exercise-induced hypertension vs. Normal blood pressure response (controls) was evaluated on Endothelium-dependent vasodilation (p=<0.05). Exercise-induced hypertension was associated with significantly impaired endothelium-dependent vasodilation compared to controls (2.81% vs 7.77%, p<0.05).