Key result
Resorbable magnesium scaffolds show slight lumen loss at 12 months, but ~98% maintain non-ischemic QFR.
Why the study?
No data were available on vessel healing and long-term physiological results after implantation of resorbable magnesium-made scaffold in human coronary arteries.
Does resorbable magnesium scaffold implantation lead to favorable vessel healing and physiological results at 12 months in patients undergoing percutaneous coronary intervention?
Observational (n=44)
Yes
Does resorbable magnesium scaffold implantation lead to favorable vessel healing and physiological results at 12 months in patients undergoing percutaneous coronary intervention?
Resorbable magnesium scaffold implantation leads to a significant decrease in mean lumen area at 12 months, but without significant functional impairment as assessed by QFR.
Answers are grounded in this paper and cite their sources.
Lumen loss without QFR impairment after magnesium scaffolds warrants caution; hypothesis-generating for durability, needs randomized confirmation.
Background No data are currently available on the process of vessel healing and long‐term physiological results after implantation of resorbable magnesium‐made scaffold (RMS) in human coronary arteries. Objectives To investigate after percutaneous coronary intervention (PCI) and at 12 months follow‐up (a) RMS resorption process and vessel healing, as judged by optical coherence tomography (OCT) imaging; and (b) physiological result of RMS implantation evaluated by quantitative flow ratio (QFR). Methods All patients successfully treated with at least one RMS from July 2016 to August 2018 at 2 Italian centers were evaluated. All cases with OCT pullback and/or coronary angiography suitable for QFR analysis performed after PCI and at 12 months were included. Resorption process was analyzed at OCT in each frame reporting presence of residual struts in the vessel. Results Forty‐four patients/forty‐nine lesions were included. 12‐months mean lumen area (LA; 7.54 ± 3.04 mm2) significantly decreased compared to mean LA recorded immediately after PCI (8.12 ± 1.89 mm2; p < .01). However, LA changes did not affect the functional result of PCI with a non‐ischemic QFR value (>0.80) in 98% of cases at 12‐months follow‐up. Protruding struts were detectable in more than half of cases and their presence was correlated with an increase in mean LA (+0.73mm2 [95% CI 0.51–0.94], p < .001). Conclusions RMS implantation in a real‐world population lead to significant decrease in mean LA without significant functional impairment. Two different patterns of RMS resorption were recorded, whose clinical significance remains to be investigated.
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Cerrato et al. (2020) conducted an observational in Coronary Artery Disease (n=44). Resorbable Magnesium Scaffold (RMS) vs. Post-PCI baseline was evaluated on Mean lumen area at 12 months (p=<0.01). Resorbable magnesium scaffold implantation resulted in a significant decrease in mean lumen area at 12 months (from 8.12 to 7.54 mm2), though functional results remained preserved with 98% of cases maintaining a non-ischemic QFR >0.80.
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