Key result
The HCV frameshift signal mediates the synthesis of three distinct proteins from overlapping reading frames, enhanced by a downstream double stem-loop structure in the presence of puromycin.
The study identifies a triple decoding function of the HCV ribosomal frameshift signal, allowing synthesis of proteins from three overlapping reading frames.
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HCV frameshifting may enable new antiviral strategies; leaves open therapeutic targeting pending in vivo and clinical validation.
Choi et al. (2003) studied Hepatitis C virus (HCV). HCV ribosomal frameshift signal was evaluated on Triple decoding function (synthesis of core protein, F protein, and 1.5-kDa protein). The HCV frameshift signal mediates the synthesis of three distinct proteins from overlapping reading frames, enhanced by a downstream double stem-loop structure in the presence of puromycin.
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