Key result
IL-8-251T allele linked to ~80% higher odds of encephalitis in EV71 hand-foot-and-mouth disease.
Why the study?
The association between the interleukin-8 gene region and susceptibility to Enterovirus 71 encephalitis in Chinese children was unclear.
Is the IL-8-251T allele associated with increased susceptibility to EV71 encephalitis in Chinese children with EV71 infection?
Case-Control (n=177)
Is the IL-8-251T allele associated with increased susceptibility to EV71 encephalitis in Chinese children with EV71 infection?
Odds Ratio: 1.8 (95% CI 1–3.2)
Absolute Event Rate: 72.2% vs 58.9%
p-value: p=0.038
The IL-8-251T allele is associated with increased susceptibility to EV71 encephalitis in Chinese children.
IL-8-251TT genotype was associated with EV71 encephalitis; hypothesis-generating for genetic risk stratification, needs validation.
The study was performed in 36 Chinese patients with Enterovirus 71 (EV71) encephalitis and 141 patients with EV71-related hand, foot and mouth disease (HFMD) without encephalitis. Genotyping was determined by polymerase chain reaction- restriction fragment length polymorphism. Patients with EV71 encephalitis had a significantly higher frequency of interleukin-8 (IL-8)-251TT genotype than patients with EV71-related HFMD without encephalitis (55.6% vs 31.2%, p = 0.023). The frequency of IL-8-251T alleles was significantly higher among patients with EV71 encephalitis than in patients with EV71-related HFMD without encephalitis (72.2% vs 58.9%, odds ratio 1.8, 95% confidence interval 1.0-3.2, p = 0.038). There were significant differences in gender, age, fever days, white blood cell count, C-reactive protein and blood glucose concentration and IL-8 levels among genotypes of IL-8-251A/T in EV71-infected patients, but no significant differences in alanine or aspartate aminotransferase, creatine kinase-myocardial isozyme and cerebrospinal fluid in patients with EV71 encephalitis. These findings suggest that the IL-8-251T allele is associated with susceptibility to EV71 encephalitis in Chinese patients.
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Li et al. (2015) conducted a case-control in Enterovirus 71 (EV71) encephalitis (n=177). EV71 encephalitis vs. EV71-related HFMD without encephalitis was evaluated on Frequency of IL-8-251T alleles (OR 1.8, 95% CI 1.0-3.2, p=0.038). EV71 encephalitis was associated with a significantly higher frequency of the IL-8-251T allele compared to EV71-related HFMD without encephalitis (72.2% vs 58.9%; OR 1.8; 95% CI 1.0-3.2; p=0.038).
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