Why the study?
Does a low-calorie diet associated with exercise improve endothelial function in healthy obese subjects?
Does a low-calorie diet associated with exercise improve endothelial function in healthy obese subjects?
Absolute Event Rate: 358% vs 211%
Short-term weight loss achieved through diet and exercise improves endothelium-dependent vasodilation in healthy obese individuals.
We read with interest the article by Sciacqua et al. (1) showing improvement of endothelial function in healthy obese subjects (no sex specified) after short-term (12–16 weeks) weight loss. By adopting a low-calorie diet associated with exercise, only two-thirds of the subjects enrolled in the study were able to achieve a reduction of at least 10% of initial weight (due to a high drop-out rate). In these subjects, maximal vasodilator response to the highest dose of acetylcholine increased from 211 to 358% of baseline, indicating improved endothelium-dependent vasodilation. The choice of obese subjects …
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Esposito et al. (2003) conducted a letter in Obesity. Low-calorie diet and exercise vs. Baseline was evaluated on Maximal vasodilator response to the highest dose of acetylcholine.
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