Correlation Analysis of Carotid Plaque in Young Patients With Newly Diagnosed Type 2 Diabetes and Platelet to Lymphocyte Ratio (PLR) and Neutrophil-Lymphocyte Ratio (NLR)

Background PLR and NLR had been reported that they may be related to carotid atherosclerotic. The relationship between PLR, NLR and carotid atherosclerotic plaque in young patients with newly diagnosed type 2 diabetes had not been clinically reported. Objectives To analyzed the relationship between platelet to lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), and carotid plaques in young patients with newly diagnosed type 2 diabetes. Methods The patients were divided into intima-media thickening (IMT)group and plaque group. The plaque group was divided into grade I, grade II and grade III groups. The counts of platelets, neutrophils, and lymphocytes were determined. Results The diagnostic effect of PLR and NLR was evaluated by Receiver Operating Characteristic Curve (ROC) and areas under the curve (AUC). The PLR and NLR values in observation group were higher than control group; two values in plaque group were higher than IMT group. The two values in t grade III plaque group were higher than in grade II. The two values in grade II plaque group were higher than grade I plaque group. The ROC of PLR and NLR were 0.722 and 0.653, the AUC of PLR and NLR were 111.086 and 2.240. PLR yielded a sensitivity of 0.789 and a specificity of 0.612. Conclusion NLR yielded a sensitivity of 0.809 and a specificity of 0.511. The PLR and NLR may be related to carotid inflammation in patients and positively correlated with carotid plaque.