Key result
Overweight black women had significantly lower baseline and post-fat load plasma PYY levels compared to age- and BMI-matched white women.
Why the study?
Are basal and post-fat load plasma peptide-YY (PYY) levels different between overweight, middle-aged black and white women?
Observational (n=24)
Are basal and post-fat load plasma peptide-YY (PYY) levels different between overweight, middle-aged black and white women?
Overweight black women have lower baseline and blunted postprandial PYY responses compared to white women, potentially contributing to enhanced obesity.
Answers are grounded in this paper and cite their sources.
Lower PYY levels were associated with black race in overweight women; leaves open whether blunted appetite suppression contributes to obesity disparities.
OBJECTIVE: To determine whether basal plasma peptide-YY (PYY) levels in overweight, middle-aged black women are different from those of white women of similar BMI and age and ascertain whether there is a difference between the two groups in plasma PYY levels in response to a liquid high fat load. RESEARCH METHODS AND PROCEDURES: Using a commercial radioimmunoassay kit, the concentration of PYY was measured at baseline and at 2, 4, 6, and 8 hours after ingesting a fatty liquid meal (86.5% of the calories from fat) in 12 black and 12 white women who were matched for age and BMI. RESULTS: PYY levels (picograms per milliliter) at baseline and at every other time-point of the test meal were significantly lower in the black than in the white group. In addition, the change in PYY concentration from baseline was lower in the black than in the white group only at 8 hours after the meal. DISCUSSION: The lower baseline level and the blunted PYY response of the black women to the fat load indicated that this signal for appetite suppression was reduced, which, in turn, might contribute to the enhanced obesity of the black women.
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Davis et al. (2005) conducted an observational in Overweight (n=24). Black race vs. White race was evaluated on Plasma PYY levels at baseline and after a liquid high fat load. Overweight black women had significantly lower baseline and post-fat load plasma PYY levels compared to age- and BMI-matched white women.
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