Key result
IGF-1 overexpression prevented ANG II-induced skeletal muscle wasting by inhibiting atrogin-1 expression via an Akt- and Foxo-1-dependent signaling pathway.
Why the study?
Does IGF-1 overexpression prevent ANG II-induced skeletal muscle atrophy in vivo?
Does IGF-1 overexpression prevent ANG II-induced skeletal muscle atrophy in vivo?
IGF-1 prevents Angiotensin II-induced skeletal muscle wasting through an Akt- and Foxo-1-dependent pathway that inhibits atrogin-1 expression, providing mechanistic insights into heart failure-associated muscle atrophy.
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Hypothesis-generating for IGF-1 modulation in HF-related muscle wasting; leaves open clinical translation.
Yoshida et al. (2010) studied ANG II-induced skeletal muscle atrophy. IGF-1 overexpression was evaluated on Skeletal muscle wasting and ubiquitin ligase expression. IGF-1 overexpression prevented ANG II-induced skeletal muscle wasting by inhibiting atrogin-1 expression via an Akt- and Foxo-1-dependent signaling pathway.
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