Key result
Overt nephropathy linked to ~340% higher ischaemic stroke risk in childhood-onset T1D.
Why the study?
Few studies have examined stroke incidence, predictors, and survival in type 1 diabetes mellitus.
What are the incidence, predictors, and survival rates of stroke in patients with childhood-onset type 1 diabetes?
Population
658 participants with childhood-onset T1DM from the Pittsburgh EDC Study
Comparison
Participants with and without incident stroke
Design
Prospective cohort study
Follow-up
18 years
Authors
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Stroke risk evaluation in T1DM remains imprecise; this observational cohort leaves open clinical implications pending confirmatory studies.
Cohort (n=658)
What are the incidence, predictors, and survival rates of stroke in patients with childhood-onset type 1 diabetes?
Hazard Ratio: 4.4 (95% CI 1.5–12.4)
Stroke in type 1 diabetes occurs early (mean age 40.2 years) and is associated with poor long-term survival, highlighting the need for aggressive management of risk factors like blood pressure, non-HDL cholesterol, and nephropathy.
Secrest et al. (2012) conducted a cohort in childhood-onset type 1 diabetes mellitus (n=658). Overt nephropathy and cardiovascular risk factors vs. Absence of risk factors was evaluated on Ischaemic stroke (HR 4.4, 95% CI 1.5-12.4). Overt nephropathy significantly predicted ischaemic stroke (HR 4.4; 95% CI 1.5-12.4) in patients with childhood-onset type 1 diabetes over 18 years of follow-up.
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