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Optically active 1,3-disubstituted and 1,1,3-trisubstituted 1,2,3,4-tetrahydro-β-carbolines were formed by the reaction of variours Nα, Nin-substituted (S)-tryptophan methyl esters with methyl propynoate or dimethyl butynedioate respectively; the stereoselectivity of the reactions is reported.
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Bailey et al. (1985) studied this question.
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