Key result
Centrifugal pumps prevent the ~250% surge in platelet aggregates caused by roller pumps in CABG.
Why the study?
Evaluation of the centrifugal pump versus roller pump effects on platelet function, hemolysis, and clinical outcome in elective coronary artery bypass surgery was needed.
Does a centrifugal pump reduce platelet activation, hemolysis, and improve clinical outcomes compared to a roller pump in patients undergoing elective CABG?
Comparison
Centrifugal pump vs roller pump during cardiopulmonary bypass
Design
Prospective randomized study
Follow-up
Up to 3 days postoperatively
Authors
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No clinical differences between pumps in elective CABG support current practice; leaves open optimal selection pending larger trials.
RCT (n=34)
randomized
Does a centrifugal pump reduce platelet activation, hemolysis, and improve clinical outcomes compared to a roller pump in patients undergoing elective CABG?
p-value: p=< 0.001
The use of a centrifugal pump during elective CABG significantly reduces postoperative platelet aggregation compared to a roller pump, though it does not significantly alter short-term clinical outcomes or hemolysis.
Andersen et al. (2003) conducted an RCT in elective coronary artery bypass surgery (n=34). Centrifugal pump vs. Roller pump was evaluated on Platelet aggregates (p=< 0.001). In elective CABG, roller pumps increased platelet aggregates by 250% at 3 hours and fivefold at 3 days postoperatively (p<0.001), whereas centrifugal pumps showed no significant changes.
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