Key result
Cardioband direct mitral annuloplasty achieves 100% successful function and significantly reduces annular dimensions in swine.
Why the study?
Preclinical safety and feasibility of a new transcatheter direct mitral annuloplasty intervention had not been reported.
Does transcatheter direct mitral annuloplasty with Cardioband demonstrate safety, feasibility, and efficacy in reducing annular size in a healthy porcine model?
Does transcatheter direct mitral annuloplasty with Cardioband demonstrate safety, feasibility, and efficacy in reducing annular size in a healthy porcine model?
Transcatheter direct mitral annuloplasty with the Cardioband device is feasible and effectively reduces annular size in an acute porcine model, supporting further development.
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Feasible in acute porcine model; leaves open translation to human mitral regurgitation therapy.
Taramasso et al. (2016) studied Healthy (preclinical animal model) (n=20). Transcatheter direct mitral annuloplasty with Cardioband vs. Pre-contraction baseline was evaluated on Successful implantation and device function. Transcatheter direct mitral annuloplasty with Cardioband was successfully implanted with 100% function in an acute porcine model, significantly reducing annular dimensions (p<0.001 vs baseline).
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