Key result
Assessment of the insulin-like growth factor (IGF) axis, alongside careful auxology, is proposed as the optimal diagnostic strategy for evaluating short stature and IGF deficiency.
Why the study?
Does assessment of the IGF axis improve the diagnostic evaluation of short stature compared to traditional GH stimulation testing?
Does assessment of the IGF axis improve the diagnostic evaluation of short stature compared to traditional GH stimulation testing?
This review suggests shifting the diagnostic paradigm for short stature from traditional growth hormone stimulation testing to the measurement of IGF-I and IGFBP-3.
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May support auxology plus IGF axis assessment over GH testing in short stature; leaves open prospective validation before practice change.
Ron G. Rosenfeld (2008) conducted a review in Short stature and Insulin-Like Growth Factor Deficiency. Assessment of the insulin-like growth factor (IGF) axis (IGF-I and IGF-binding protein-3) vs. Traditional growth hormone (GH) provocative testing was evaluated. Assessment of the insulin-like growth factor (IGF) axis, alongside careful auxology, is proposed as the optimal diagnostic strategy for evaluating short stature and IGF deficiency.
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