Key result
Antihypertensive use is linked to a ~7-fold increase in SBP changes among postmenopausal women.
Why the study?
Factors influencing blood pressure variability in postmenopausal women were not well identified based on longitudinal data from the China Health and Nutrition Survey.
Observational (n=346)
Odds Ratio: 7.293 (95% CI 2.191–24.275)
In postmenopausal women, specific demographic and clinical factors including age, BMI, hip circumference, alcohol consumption, and marital status are associated with distinct longitudinal trajectories of systolic and diastolic blood pressure.
BACKGROUND: The aim is to identify the factors influencing blood pressure variability in postmenopausal women based on the China Health and Nutrition Survey (CHNS). MATERIAL AND METHODS: The data on postmenopausal women between 1993 and 2015 were extracted from the CHNS. Group-based trajectory modeling was used to analyze the development track of blood pressure changes, based on which the subjects were separately divided into two groups for systolic blood pressure (SBP) and diastolic blood pressure (DBP). Univariate and multivariate analyzes were performed to analyze the factors influencing SBP and DBP. RESULTS: A total of 346 women were eligible for the study. Group-based trajectory modeling showed two different trajectories of blood pressure, including the low-level, slowly developed type and the high-level, rapidly developed, stable type of SBP, as well as the low-level, slowly developed type and the high-level, slowly developed type of DBP. In multivariate analysis, age (odds ratio [OR]: 1.118, 95% confidence interval [CI]: 1.082-1.156), body mass index (BMI) (OR: 2.239, 95%CI: 1.010-4.964), antihypertensive agents (OR: 7.293, 95%CI: 2.191-24.275), hip circumference (OR: 1.069, 95%CI: 1.014-1.128) and marital status (OR: 3.103, 95%CI: 1.028-9.361) were found to be the significant factors influencing SBP; age (OR: 1.067, 95%CI: 1.039-1.096), alcohol consumption (OR: 2.741, 95%CI: 1.169-6.429), antihypertensive agents (OR: 4.577, 95%CI: 1.553-13.492), hip circumference (OR: 1.093, 95%CI: 1.049-1.138), and marital status (OR: 3.615, 95%CI: 1.228-10.644) were the predominant factors influencing DBP. CONCLUSIONS: In postmenopausal women, age, BMI, antihypertensive agents, hip circumference, and marital status are associated with SBP changes, while age, alcohol consumption, antihypertensive agents, hip circumference, and marital status with DBP variability. MESH KEYWORDS: postmenopausal women, blood pressure, development track, influencing factors, CHNS.
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Tao et al. (2023) conducted an observational in Blood pressure variability (n=346). Antihypertensive agents was evaluated on Systolic blood pressure (SBP) changes (OR 7.293, 95% CI 2.191-24.275). In postmenopausal women, antihypertensive agents were strongly associated with systolic blood pressure changes (OR 7.293; 95% CI 2.191-24.275), alongside age, BMI, hip circumference, and marital status.
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