La corrélation entre la variation des paramètres biologiques prothrombotiques et le diabète et ses complications vasculaires

Introduction. To study the routine parameters of coagulation and assess their relationship with microvascular complications after 5 years of development of type 2 diabetes. Patients and methods. A prospective cross-sectional study consisted of 50 type 2 diabetics (T2D) with presence or absence of microvascu- lar complications, older than 40 years whose disease was confirmed for at least five years and recruited consultation of Internal Medicine Department of General Hospital of Grand-Yoff and a control population consisted of 50 subjects free of diabetes and glucose intolerance. Results. The study population consists of 50 type 2 diabetics with a sex ratio which is equal to 1.94 and a mean age of 62.08 ± 9.74 years. The frequency of microvascular complications was 53.85%, 30.77% and 15.38% for retinopathy, peripheral arterial disease and nephropathy. Blood glucose, HbA1c, the fibrinogenemia, platelet counts and TCA patient / TCA control ratio were significantly higher in T2D than in controls (p <0.01). Raising the fibrinogenemia in T2D with microvascular complications compared with T2D without microvascular complications was statistically significant (p = 0.02, p<0.01). The OR was equal to 2.83 between T2D microvascular complications and microvascular complica- tions T2D and 4.75 between type 2 diabetics and controls. Conclusion. Thrombosis present in type 2 diabetes is much more common when it is accompanied by microvascular complications.