Key result
Hypertension linked to ~52% higher prevalence of bone mineral density disturbances in elderly women.
Why the study?
The relationship between central aortic pressure, pulse wave indices, and bone mineral density in elderly women with uncomplicated essential hypertension was not well characterized.
Cross-Sectional (n=55)
Absolute Event Rate: 43.3% vs 28.5%
Elderly women with controlled arterial hypertension and elevated vascular stiffness have decreased bone mineral density compared to healthy peers, suggesting a link between vascular and bone health.
Findings in small observational cohort of postmenopausal hypertensive women are hypothesis-generating; larger prospective studies needed.
The aim — to perform a comparative analysis of the indices of central aortic pressure and pulse wave, bone mineral density (BMD) in elderly female patients with uncomplicated essential hypertension.Materials and methods. The study involved 30 women with essential hypertension of II stage, 2 degree, of mean age of 69.3 ± 0.9 years, with a postmenopausal duration of 17.7 ± 1.1 years and 25 practically healthy women aged 65.6 ± 1.6 years with a postmenopausal period of 15 ± 1.6 years. All patients underwent general clinical and laboratory examination, daily monitoring of blood pressure (BP) and echocardiography. The parameters of central hemodynamics and arterial stiffness were measured with SphygmoCor (AtCor Medical, Australia). BMD was examined on Hologic Discovery apparatus. To assess the quality of bone tissue (Trabecular Bone Score — TBS), the TBS iNsight technique, developed by MedImaps (France), was used.Results and discussion. Patients with essential hypertension and those of the control group were matched by age, body mass index, brachial and central arterial pressure and the level of markers of bone remodeling. A violation in BMD was found in 13 (43.3 %) patients of the main group (in 9 (30 %) women — osteopenia, in 4 — osteoporosis (13.3 %). In the control group, BMD disturbances were detected in 7 (28.5 %) women (4 (16.3 %) had osteopenia, and 3 (12.2 %) — osteoporosis). Patients with hypertension had a positive correlation between PPampl. and BMD indices of the total skeleton, lumbar spine (L1—L4) and the ultradistal forearm bones, the index of bone tissue remodeling (P1NP) and the quality of trabecular bone tissue — TBS; a negative correlation between the value of the Ttest in the total skeleton, lumbar spine and neck of the left femur with the parameters of applanation tonometry (AP, AIx, AIx75) and a positive relationship between AP, AIx and FRAXall.Conclusions. Elderly women with controlled arterial hypertension and elevated vascular stiffness (according to applanation tonometry) have decreased BMD compared with practically healthy women of comparable age.
No takes yet. Share an insight, caveat, or question.
En et al. (2018) conducted a cross-sectional in Uncomplicated essential hypertension (n=55). Essential hypertension vs. Practically healthy women was evaluated on Bone mineral density (BMD) disturbances (osteopenia or osteoporosis). Elderly women with essential hypertension had a higher prevalence of bone mineral density disturbances (43.3%) compared to practically healthy women (28.5%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: