Key result
Intra-arterial heparin flushing aids refractory hypertension in bilateral renal artery stenosis.
Why the study?
Refractory hypertension with bilateral renal artery stenosis and limited revascularization options presents a therapeutic challenge in young patients with end-stage renal disease.
Does intra-arterial heparin flushing improve blood pressure control in a patient with refractory hypertension and bilateral renal artery stenosis?
Case Report (n=1)
Does intra-arterial heparin flushing improve blood pressure control in a patient with refractory hypertension and bilateral renal artery stenosis?
Intra-arterial heparin flushing may be considered as a salvage therapy for blood pressure control in patients with refractory hypertension due to unsalvageable bilateral renal artery stenosis.
Hypothesis-generating for refractory hypertension in ESRD with renal artery stenosis; prospective trials needed before clinical adoption.
Refractory hypertension is a type of hypertension that requires special attention. Secondary causes of hypertension should be considered when uncontrolled blood pressure is present, especially in younger patients (<30 years). In this case, the presence of bilateral renal artery stenosis resulted in refractory hypertension and end-stage renal disease requiring renal replacement therapy in the form of hemodialysis. The main challenges will be discussed in this case is to deliver the most beneficial therapy considering the very limited option for revascularization therapy because of the late presentation of patient's condition. Intra-arterial heparin flushing was chosen for this patient to consider the advantages over the risks arising from the actions taken.
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Putra et al. (2019) conducted a case report in Refractory hypertension and bilateral renal artery stenosis (n=1). Intra-arterial heparin flushing was evaluated. Intra-arterial heparin flushing was utilized as a novel therapeutic approach for a patient with refractory hypertension and end-stage renal disease due to bilateral renal artery stenosis.
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