Key result
ACE inhibitory peptide LVLPGE lowers systolic blood pressure by up to ~39 mmHg in hypertensive rats.
Why the study?
The gastrointestinal digestion, transport, and in vivo antihypertensive effects of the ACE inhibitory peptide LVLPGE at different doses were evaluated to understand its pharmacokinetics and efficacy.
Does the ACE inhibitory peptide LVLPGE reduce systolic blood pressure in spontaneous hypertensive rats?
Does the ACE inhibitory peptide LVLPGE reduce systolic blood pressure in spontaneous hypertensive rats?
The ACE inhibitory peptide LVLPGE demonstrates high gastrointestinal stability, effective intestinal transport, and significant in vivo antihypertensive effects in spontaneous hypertensive rats.
Supports development of food-derived antihypertensives; leaves open clinical translation pending human trials.
The angiotensin-converting enzyme (ACE) inhibitory peptide LVLPGE provides outstanding antihypertensive effects in vivo, with a maximum systolic blood pressure (SBP) drop of 39 mmHg at a dose of 10 mg/kg. We evaluated the gastrointestinal digestion, transport, and in vivo antihypertensive effects of LVLPGE at different doses. LVLPGE was resistant to gastrointestinal enzymes with a stability of 97.8% and a permeability P app of (5.09 ± 0.94) × 10 –7 cm/s. LVLPGE was mainly transported through the Caco-2 cell monolayer by the peptide transporter PepT 1 and passive-mediated transport. LVLPGE at doses of 30 and 50 mg/kg had a positive antihypertensive effect in vivo; 30 mg/kg had a more significant effect than 50 mg/kg. After oral administration, the pharmacokinetics of LVLPGE showed that the C max was 4.65 ng/mL at 2 min. The blood pressure-lowering effect increased as the concentration of LVLPGE increased in the plasma of spontaneous hypertensive rats (SHRs).
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Pei et al. (2021) studied Hypertension. LVLPGE was evaluated on Systolic blood pressure (SBP) drop. The ACE inhibitory peptide LVLPGE produced a maximum systolic blood pressure drop of 39 mmHg at a dose of 10 mg/kg in spontaneous hypertensive rats.
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