Key result
Cephalothin prophylaxis in open-heart surgery is linked to low late-infection rates and 0 nephrotoxic reactions.
Why the study?
Does cephalothin sodium prevent post-operative infections and is it safe in patients undergoing open-heart surgery?
Observational (n=100)
Does cephalothin sodium prevent post-operative infections and is it safe in patients undergoing open-heart surgery?
Cephalothin sodium appears to be a safe and effective prophylactic antibiotic for patients undergoing open-heart surgery.
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May support cephalothin prophylaxis safety in open-heart surgery; leaves open efficacy confirmation in randomized trials.
Bain et al. (1977) conducted an observational in Open-heart surgery (n=100). Cephalothin sodium was evaluated on Post-operative infections, immune reactions, and nephrotoxic effects. Cephalothin sodium prophylaxis (28 g over 48 h) in 100 open-heart surgery patients resulted in a low incidence of late-onset infections and 0 immune or nephrotoxic reactions.
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