Key result
High-dose warfarin manages recurrent DVT in ESRD harboring a rare C20209T prothrombin mutation.
Why the study?
The significant morbidity and mortality associated with venous thromboembolism have prompted investigations to identify rare inherited causes beyond common mutations.
Case Report (n=1)
Identifies a rare C20209T prothrombin gene mutation as a cause of recurrent DVT in an ESRD patient, which was successfully managed with high-dose warfarin.
May warrant prothrombin gene testing in ESRD with recurrent DVT; leaves open optimal anticoagulation strategies.
Venous thromboembolism (VTE) represents the formation of a blood clot in one of the deep veins of human body. The significant morbidity and mortality rates associated with VTE have spurred increasing investigations seeking to identify causative factors for this complex condition. While the most frequent causes of an inherited hypercoagulable state are the Factor V Leiden mutation and the prothrombin gene mutation, polymerase chain reaction (PCR) analysis has helped to identify other rare causes of inherited VTE. We report a case of a recurrent deep venous thrombosis in an end-stage renal disease patient. All laboratory tests for hypercoagulable states were normal. However, PCR analysis detected a rare polymorphism of prothrombin gene mutation at position C20209T, instead of G20210A. The patient was treated successfully with a high dose of warfarin to maintain adequate anti-coagulation during the 2-year follow-up.
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Bani‐Hani et al. (2014) conducted a case report in Recurrent deep venous thrombosis in end-stage renal disease (n=1). High dose of warfarin was evaluated on Adequate anti-coagulation and prevention of recurrent deep venous thrombosis. A rare C20209T prothrombin gene mutation was identified in an end-stage renal disease patient with recurrent deep venous thrombosis, who was successfully treated with high-dose warfarin over 2 years.
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