Key result
Masked hypertension is linked to ~22% higher carotid intima-media thickness versus normotension.
Why the study?
The progression of functional and structural arterial changes in masked hypertensive patients detected by home blood pressure was not well characterized.
Is masked hypertension associated with increased arterial wall stiffness and atherosclerosis compared to normotension in outpatients not on antihypertensive medication?
Cross-Sectional (n=156)
Is masked hypertension associated with increased arterial wall stiffness and atherosclerosis compared to normotension in outpatients not on antihypertensive medication?
Masked hypertension detected by home blood pressure monitoring is associated with significant subclinical structural and functional arterial damage, comparable to sustained hypertension.
Answers are grounded in this paper and cite their sources.
Supports home BP monitoring to detect masked hypertension; hypothesis-generating for its role in arterial damage, pending prospective trials.
We consecutively enrolled 156 outpatients (mean age: 69.5 years) without antihypertensive medication, and classified them into 4 subgroups (Normotension; NT, White Coat Hypertension; WCHT, Masked Hypertension; MHT, Sustained Hypertension; SHT) by using home (135/85 mmHg) and office (140/90 mmHg) blood pressure (BP) values. These 4 subgroups were compared with arterial wall stiffness assessed by brachial-ankle pulse wave velocity (baPWV) and atherosclerosis assessed by carotid intima-media thickness (CIMT). Patients with MHT (72.5 years) and SHT (71.0 years) were older than other groups, but comparable with other parameters. BaPWV was higher in the MHT (1978.1 cm/sec) and in the SHT (2167.1 cm/sec) than in the other groups. CIMT was higher in the MHT (0.88 mm) than in the NT (0.72 mm) and the WCHT (0.77 mm). In conclusion, this study suggests that the functional and structural changes in the arteries progress in masked hypertensive patients detected by home BP.
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Matsui et al. (2005) conducted a cross-sectional in Hypertension (n=156). Masked Hypertension (MHT) vs. Normotension (NT) and White Coat Hypertension (WCHT) was evaluated on Carotid intima-media thickness (CIMT). Masked hypertension was associated with higher arterial wall stiffness and carotid intima-media thickness.
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