Key result
CRT review highlights evolving roles in prevention and personalized care within 5P medicine frameworks.
Why the study?
The indications and role of cardiac resynchronisation therapy in heart failure continue to evolve beyond curative treatment, requiring a comprehensive review from the perspective of 5P medicine.
This review summarizes the evolving role of cardiac resynchronization therapy in heart failure management through the framework of 5P medicine (preventive, personalized, predictive, participatory, promotive).
Chronic heart failure is still a major challenge for healthcare. Currently, cardiac resynchronisation therapy (CRT) has been incorporated into the updated guideline for patients with heart failure, left ventricular ejection fraction ≤35 % and prolonged QRS duration. With 20 years of development, the concept of 'from bench to bedside' has been illustrated in the field of CRT. Given the fact that the indications of CRT keep evolving, the role of CRT is not limited to the curative method for heart failure. We therefore summarise with the perspective of 5P medicine - preventive, personalised, predictive, participatory, promotive, to review the benefit of CRT in the prevention of heart failure in those with conventional pacemaker indications, the individualised assessment of patient's selection, the predictor of responders of CRT, and the obstacles hindering the more application of CRT and the future development of this device therapy.
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Fang et al. (2015) conducted a review in Chronic heart failure. Cardiac resynchronisation therapy (CRT) was evaluated. Cardiac resynchronisation therapy in heart failure is reviewed from the perspective of 5P medicine, highlighting its evolving role in prevention, personalized assessment, and future development.
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