First inappropriate implantable cardioverter defibrillator therapy is often due to inaccurate device programming: analysis of the French OPERA registry
Key result
Improved ICD programming could prevent ~50% of first inappropriate therapies in device recipients.
- n=636
Why the study?
Inappropriate therapy delivered by implantable cardioverter defibrillators remains a challenge and determinants of first inappropriate therapies need clarification.
Population
636 ICD recipients from the French OPERA registry with single-, dual-, or triple-chamber devices
Comparison
First appropriate therapy vs first inappropriate therapy
Design
Observational registry study
Follow-up
22.8 ± 8.8 months
Authors
Discussion
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Implication
ICD programming optimization may reduce inappropriate therapies; observational data leaves open need for randomized confirmation.
Study Design
Type
Observational (n=636)
Structured PICO
P
Population
636 patients (88% men, mean age 62 years) receiving single-, dual-, or triple-chamber ICDs for primary or secondary indications, followed for a mean of 22.8 months.
E
Exposure
Implantable cardioverter defibrillator (ICD) therapy (single-, dual-, or triple-chamber)
O
Outcome
Times to and determinants of first appropriate (FAT) and inappropriate (FIT) therapiessafety
Nearly half of first inappropriate ICD therapies could be prevented by optimizing device programming, highlighting the importance of tailored device settings.
Cite This Study
Leenhardt et al. (2012) conducted an observational in Implantable cardioverter defibrillator (ICD) recipients (n=636). Implantable cardioverter defibrillator (ICD) was evaluated on First inappropriate therapy (FIT). First inappropriate therapy occurred in 11% of ICD recipients followed for approximately 2 years, and nearly 50% of these therapies could have been prevented by improving device programming.