Multiparametric cardiovascular magnetic resonance assessment of cardiac allograft vasculopathy

Cardiac allograft vasculopathy (CAV) continues to limit the long-term survival of heart transplant recipients. CAV affects both the epicardial arteries and the microvessels, however it does so independently, and epicardial and microvascular disease are both independently predictive of prognosis. Despite being associated with considerable limitations, coronary angiography has a class I recommendation for CAV surveillance and annual or biannual surveillance angiography is performed routinely in most centers. The aim of this study was to evaluate the diagnostic performance of multiparametric CMR in CAV, and to compare the performance of CMR to that of invasive coronary angiography, using contemporary invasive epicardial artery and microvascular assessment techniques as reference standards. All transplant recipients referred for surveillance angiography at a single UK transplant center over a 2-year period were prospectively screened for study eligibility. Patients prospectively underwent coronary angiography followed by coronary intravascular ultrasound (IVUS; epicardial artery reference standard) and index of microcirculatory resistance (IMR; microvascular reference standard). Within one month patients underwent multiparametric CMR. CMR assessment included LV volumetrics, circumferential strain and strain rate, torsion (circumferential-longitudinal shear), pixel-wise absolute myocardial blood flow quantification using generalized Tikhonov deconvolution with a b-spline representation of the impulse response function, late gadolinium enhancement and T1 mapping/extracellular volume measurement. Angiographic and CMR data were compared with the invasive epicardial artery (IVUS intima-media ("plaque") volume index) and microvascular (IMR) reference standards. In addition, 10 age- and sex-matched healthy volunteers underwent CMR. Forty-eight patients were recruited; median 7.1 years (IQR 4.6-10.3) since transplantation. Mean IVUS plaque volume index was 22.4 ± 9.8%; mean IMR was 23.7 ± 12.5. Selected univariable and multivariable associations between patient, angiographic and CMR data and IVUS plaque volume index and IMR are summarized in Table 1 . CMR myocardial perfusion reserve was the only independent predictor of both epicardial (β = -0.57, p < 0.001) and microvascular disease (β = -0.60, p < 0.001) on stepwise multivariable regression. Myocardial perfusion reserve outperformed angiography for detecting moderate CAV (AUC 0.89, 95% confidence intervals 0.79-1.0 v 0.59 (0.42-0.77) respectively, p = 0.01; Figure 1A ) and severe CAV (AUC 0.88 (0.78-0.98) v 0.67 (0.52-0.82), p = 0.05; Figure 1B ). Diagnostic performance of cardiovascular magnetic resonance myocardial perfusion reserve and angiography for detecting cardiac allograft vasculopathy (CAV) . Diagnostic performance of cardiovascular magnetic resonance myocardial perfusion reserve (CMR) and angiography (angio) for detecting; (A) moderate cardiac allograft vasculopathy, defined as > median epicardial or microvascular disease; and (B) severe cardiac allograft vasculopathy, defined as > 75th centile epicardial or microvascular disease. CAV, including epicardial and microvascular components, can be detected more accurately using non-invasive CMR-based absolute myocardial blood flow assessment than with invasive coronary angiography, the current clinical surveillance technique.