What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Diabetes with elevated blood pressure and essential hypertension (n=93). Intervention: Diabetic nephropathy vs. Essential hypertension and healthy controls. Primary outcome: Relationship between urinary albumin excretion (UAE) and blood pressure (BP).

What does this research mean for the field?

Plotting urinary albumin excretion against blood pressure allows near-complete differentiation between diabetic patients with nephropathy and patients with essential hypertension. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate whether diabetic patients with essential hypertension can be clinically distinguished from diabetic patients experiencing high blood pressure due to diabetic nephropathy.

January 1, 1987Scandinavian Journal of Clinical and Laboratory Investigation

Increased blood pressure in diabetes: Essential hypertension or diabetic nephropathy?

Q: What are the key findings of this study?

Plotting urinary albumin excretion against blood pressure nearly totally separated diabetic patients with nephropathy from non-diabetic patients with essential hypertension.

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Key result

Plotting urinary albumin excretion against blood pressure clearly distinguishes diabetic nephropathy from essential hypertension.

n=93

Why the study?

It is unclear whether it is possible to distinguish between diabetics with essential hypertension and diabetics with elevated blood pressure due to diabetic nephropathy.

Can urinary albumin excretion and blood pressure distinguish between essential hypertension and diabetic nephropathy in diabetic patients?

Key Points

To evaluate whether diabetic patients with essential hypertension can be clinically distinguished from diabetic patients experiencing high blood pressure due to diabetic nephropathy.
Evaluated 46 young diabetic patients aged 25–40 years, categorized as having incipient nephropathy (UAE >15 µg/min, protein <0.5 g/24 h; n=21) or overt nephropathy (protein ≥0.5 g/24 h; n=25).
Compared diabetic participants against 23 non-diabetic patients with essential hypertension and 24 healthy control subjects aged 25–40 years by assessing blood pressure and urinary albumin excretion.
Plotting urinary albumin excretion against blood pressure enabled near-total separation between diabetic patients and non-diabetic patients with essential hypertension.
At identical mean arterial blood pressure levels (125 mmHg), diabetic patients showed 100-fold higher urinary albumin excretion than non-diabetic essential hypertensive subjects.
Five diabetic patients with normal urinary albumin excretion and elevated blood pressure (≥160/95 mmHg) clustered entirely within the distribution of essential hypertension patients.

Study Design

Type

Cross-Sectional (n=93)

Structured PICO

Can urinary albumin excretion and blood pressure distinguish between essential hypertension and diabetic nephropathy in diabetic patients?

Population

93 males and females aged 25 to 40 years, including diabetics with incipient or overt nephropathy, patients with essential hypertension, and healthy controls.

Outcome

Distinction between diabetics with essential hypertension and diabetics with elevated blood pressure due to diabetic nephropathy using urinary albumin excretion and blood pressure.surrogate

Plotting urinary albumin excretion against blood pressure can effectively distinguish diabetic patients with essential hypertension from those with elevated blood pressure due to diabetic nephropathy.

Discussion

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Implication

May aid differentiation of diabetic nephropathy from essential hypertension; hypothesis-generating, requires prospective validation before practice change.

Cite This Study

Christensen et al. (1987) conducted a cross-sectional in Diabetes with elevated blood pressure and essential hypertension (n=93). Diabetic nephropathy vs. Essential hypertension and healthy controls was evaluated on Relationship between urinary albumin excretion (UAE) and blood pressure (BP). Plotting urinary albumin excretion against blood pressure nearly totally separated diabetic patients with nephropathy from non-diabetic patients with essential hypertension.

synapsesocial.com/papers/6ab8dbbdf2b991d8c807aa3f https://doi.org/10.1080/00365518709168915

Topics

Hypertension management

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Implication

May aid differentiation of diabetic nephropathy from essential hypertension; hypothesis-generating, requires prospective validation before practice change.

Increased blood pressure in diabetes: Essential hypertension or diabetic nephropathy?

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Topics

Increased blood pressure in diabetes: Essential hypertension or diabetic nephropathy?

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

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Topics

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