Key result
Blood from high-output anemic donors alters recipient cardiovascular hemodynamics compared to normal blood.
Why the study?
The mechanism underlying increased cardiac output in severe anemia was unclear, with a possible humoral influence hypothesized.
Does infusion of blood from anemic dogs with augmented cardiac output produce cardiovascular changes in normal dogs?
Does infusion of blood from anemic dogs with augmented cardiac output produce cardiovascular changes in normal dogs?
This preclinical study suggests that a humoral factor contributes to the increased cardiac output observed during severe anemia.
Answers are grounded in this paper and cite their sources.
Indicates humoral factor in canine high-output anemia; leaves open existence and relevance in humans.
The possibility that the increased cardiac output observed in severe anemia is due to a humoral mechanism was investigated by an assay procedure in which blood from anemic donor dogs was infused into normal assay dogs. Blood removed from anemic donors during the period of augmented cardiac output and infused into assay dogs produced cardiovascular changes which were statistically different from the changes observed with infusions of normal blood or blood removed from anemic donors when the cardiac output was not elevated.
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Justus et al. (1957) studied Acute and chronic posthemorrhagic anemia. Infusion of blood from anemic donor dogs during augmented cardiac output vs. Infusion of normal blood or blood from anemic donors when cardiac output was not elevated was evaluated on Cardiovascular changes. Infusion of blood from anemic donor dogs during augmented cardiac output produced statistically different cardiovascular changes in normal assay dogs compared to normal blood.
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