Key result
Moderate muscular exercise after blood losses up to 20% of blood volume provoked an effective cardiovascular reaction and normal circulatory adaptation in dogs despite depressed rest values.
Dogs can maintain effective cardiovascular adaptation to moderate exercise despite blood losses up to 20% of their blood volume.
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Caution against human extrapolation; hypothesis-generating for compensatory mechanisms in hypovolemic exercise.
The cardiovascular adaptation to a moderate muscular exercise after hemorrhages up to 35 % of the circulatory blood volume was investigated in anesthetized and unanesthetized dogs. The systematic study of the different cardiovascular parameters shows that, after hemorrhage, a moderate muscular exercise provokes a relatively more important hemodynamic acceleration with regard to the control values. This more pronounced solicitation allows, within certain limits, actually a ← normal → circulatory adaptation despite the obviously depressed rest values: an effective cardiovascular reaction was observed in our experiments after blood losses up to 20 % of the blood volume. The results obtained from anesthetized and unanesthe-tized dogs are found to be comparable.
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Vanhoutte et al. (1966) studied Hemorrhage. Moderate muscular exercise after graded hemorrhages vs. Control values (rest values) was evaluated on Cardiovascular adaptation and hemodynamic acceleration. Moderate muscular exercise after blood losses up to 20% of blood volume provoked an effective cardiovascular reaction and normal circulatory adaptation in dogs despite depressed rest values.
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