Key result
Amiodarone causes reversible pulmonary toxicity mimicking metastatic lung cancer in a case report.
Why the study?
Amiodarone can cause pulmonary toxicity that mimics metastatic lung disease, which may complicate diagnosis and management.
Case Report (n=1)
Amiodarone can cause reversible pulmonary toxicity that radiologically mimics metastatic lung disease.
Amiodarone toxicity should enter the differential for new lung lesions in treated patients; this case report leaves open incidence and risk stratification.
A 65 year old man developed atrial arrhythmias secondary to a congestive cardiomyopathy which were resistant to quinidine and disopyramide. Amiodarone controlled the paroxysmal atrial tachycardia but 4 months after starting the drug he developed increasing dyspnoea and radiological changes highly suggestive of metastatic lung disease. Lung biopsy showed change of drug-induced pneumonitis and 4 months after stopping amiodarone his symptoms resolved and the chest X-ray had cleared. Amiodarone may cause pulmonary toxicity mimicking metastatic lung disease.
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Patel et al. (1987) conducted a case report in Atrial arrhythmias secondary to congestive cardiomyopathy (n=1). Amiodarone was evaluated on Pulmonary toxicity mimicking metastatic lung disease. Amiodarone therapy caused pulmonary toxicity mimicking metastatic lung disease in a 65-year-old man, which resolved 4 months after discontinuing the drug.
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