Key result
Low-dose amiodarone (200 mg/day) caused reversible tumour-like pulmonary abnormalities mimicking lung cancer in a 74-year-old woman after more than 2.5 years of therapy.
Case Report (n=1)
Low-dose amiodarone therapy can cause reversible tumour-like pulmonary abnormalities that mimic lung cancer.
Clinicians should consider amiodarone toxicity in unexplained pulmonary masses; case reports leave open incidence and monitoring needs.
A 74-year-old woman presented with a one-week history of persistent cough. A chest x-ray and computed tomography images revealed features mimicking lung cancer, which included a large solitary consolidation and hilar lymphadenopathy. She had received low-dose amiodarone (200 mg/day) for treatment of atrial fibrillation for more than 2.5 years. The tumour-like abnormalities did not disappear until the discontinuation of amiodarone therapy. The finding of low-dose amiodarone causing tumour-like abnormalities on a chest x-ray is unique. Once amiodarone-induced tumour-like changes are diagnosed, therapeutic options are limited. In most cases, the tumour-like changes are reversible, if diagnosed early. An unusual case involving amiodarone-induced pulmonary abnormalities is reported, followed by a review of the relevant literature.
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Cheng et al. (2010) conducted a case report in Atrial fibrillation (n=1). Low-dose amiodarone was evaluated on Tumour-like pulmonary abnormalities mimicking lung cancer. Low-dose amiodarone (200 mg/day) caused reversible tumour-like pulmonary abnormalities mimicking lung cancer in a 74-year-old woman after more than 2.5 years of therapy.
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