Amiodarone pulmonary toxicity can mimic malignant lung tumors on FDG-PET and CT, presenting a significant diagnostic challenge due to late resolution after drug withdrawal.
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Amiodarone toxicity should enter differentials for FDG-avid lung masses; this case extends recognized mimics and documents delayed post-withdrawal resolution.
A 64 year old man receiving long term amiodarone treatment presented with dyspnea, cough, and weight loss. Radiographs and computed tomography showed a lung mass with associated multiple pulmonary nodules. Biopsies of the pulmonary mass showed foamy histiocytes without malignant cells. However, findings on FDG-PET scan were consistent with a malignant tumour. These findings on computed tomography and PET scan and the unusually late resolution of the pulmonary lesions after withdrawal of amiodarone treatment posed a challenging diagnostic problem.
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Azzam et al. (2006) studied this question.
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